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Abstract Introduction: Evidence in non-ocular tissues indicate that the antioxidant glutathione (GSH) may be regulated in a circadian manner leading to the idea that GSH levels in the lens may also be controlled in a circadian manner to anticipate periods of oxidative stress

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TB-500 is a synthetic fragment of thymosin 4 (residues 1723, sequence Ac-LKKTETQ) and is not identical to full-length thymosin 4 or to recombinant human thymosin 4 used in clinical trials

2014;5:e0143814

Importantly, multiple layers of interconnections exist between different modalities of regulated cell death, including shared triggers, molecular components and protective mechanisms